Difference Between Lock And Key Model And Induced Fit Model Of Enzyme Action

They are lock and key theory and induced fit theory.

Difference between lock and key model and induced fit model of enzyme action.

The way a key the substrate fits into a lock the enzyme. Induced fit and lock and key are the two models which describe the mechanism of action of the enzyme. Whereas in the lock and key theory the substrate and the active site of the enzyme are complementary in shape at the beginning. Daniel e koshland formulated this hypothesis in 1959.

According to this hypothesis the active site does not have a rigid lock and key conformation. They are important in describing how enzymes increase the rate of a biological reaction through catalysis. In this theory the substrate fits into an active site like a key into a lock. Similarities between induced fit and lock and key model.

Two main theories are used to explain how enzyme substrate complexes form. Instead the substrate interacts with the active site and both change their shape to fit together. In this model though the key and the enzyme active site do not fit perfectly together. The lock and key model and the induced fit hypothesis are two potential models for how substrates may bind in the active site of an enzyme.

The binding of the substrate molecule to the enzyme molecule induces to modify the shape of the active site so that it becomes complementary to the substrate molecule. The induced fit model is an elaboration on the basic idea of the lock and key model. Enzymes have very precise shape which includes a cleft or pocket called active sites. There is no change in shape of the active site.